United and Arsenal will play out the tie of the round after being paired together in the FA Cup last 16.
Having overcome Tottenham in Sunday's thrilling tie at Old Trafford, the Reds will now entertain Arsene Wenger's side at Old Trafford in the fifth round of the competition.
The Reds may feel slightly unfortunate to have drawn such difficult opponents, especially as Chelsea and Liverpool were handed home ties against Huddersfield and Barnsley respectively.
Incredibly, United have now drawn Premier League opposition in each of the last 10 FA Cup ties (plus two replays). In order, they are: Arsenal, Tottenham, Aston Villa, Chelsea, Watford, Middlesbrough, Reading, Portsmouth, Aston Villa, Liverpool.
The full draw is as follows:
Bristol Rovers v Southampton
Cardiff v Wolves
Sheffield United v Middlesbrough
Liverpool v Barnsley
United v Arsenal
Preston v Portsmouth
Coventry v West Brom
Chelsea v Huddersfield
Labels: Man Utd FC